Pathogenetic Significance of Fetal-Type Acetylcholine Receptors on Thymic Myoid Cells in Myasthenia Gravis
نویسندگان
چکیده
منابع مشابه
Pathogenetic Significance of Fetal-Type Acetylcholine Receptors on Thymic Myoid Cells in Myasthenia Gravis
To investigate the role of thymic myoid cells in the pathogenesis of myasthenia gravis (MG), mRNA of nonneoplastic thymuses from eight MG patients was analyzed by dot blot hybridization for the occurrence of acetylcholine receptor (AChR) subunit transcripts, using the five AChR-subunit cDNAs (alpha, beta, gamma, delta, and epsilon) as probes. Attention was particularly paid to the gamma- and ep...
متن کاملAutoimmunity to acetylcholine receptors in myasthenia gravis.
19. Wells, J.. Isbister, J. & Kies, C. (1987) in Basic and Clinical Immunology (Stites, D., Stobo, J. & Wells, J.. eds.). 6th edn, pp. 405-416, Appleton Lange. London Rose, N., Lorenzi, M. & Lewis, M. (1987) in Basic and Clinical Immunology (Stites, P., Stobo. J. & Wells, J., eds.), 6th edn, pp. 582-598, Appleton Lange, London Coombs, S. & Gel, P. (1975) in Clinical Aspects of Immunology (Gel, ...
متن کاملFetal acetylcholine receptor inactivation syndrome and maternal myasthenia gravis.
Fetal acetylcholine receptor inactivation syndrome is a rare condition occurring in newborns of myasthenic mothers, characterized by bulbar and facial weakness after recovery from the generalized muscle weakness. Antibodies against fetal subunit of acetylcholine receptor seem to have a pathogenetic role leading to long-lasting injury in vulnerable muscle groups. We report a girl, born to a myas...
متن کاملAcetylcholine receptors and end-plate electrophysiology in myasthenia gravis.
and 'Immunological associations of acquired neuromyotonia (Isaacs' syndrome). Report of five cases and literature review'. John Newsom-Davis published 12 original articles in Brain. Many dealt with autoimmunity in disorders of the neuromuscular junction or peripheral nerve. Together this work provided a foundation for knowledge on disorders resulting from autoantibodies directed at the acetylch...
متن کاملIgG1 antibodies to acetylcholine receptors in ‘seronegative’ myasthenia gravis†
Only around 80% of patients with generalized myasthenia gravis (MG) have serum antibodies to acetylcholine receptor [AChR; acetylcholine receptor antibody positive myasthenia gravis (AChR-MG)] by the radioimmunoprecipitation assay used worldwide. Antibodies to muscle specific kinase [MuSK; MuSK antibody positive myasthenia gravis (MuSK-MG)] make up a variable proportion of the remaining 20%. Th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Immunology
سال: 1992
ISSN: 1044-6672
DOI: 10.1155/1992/40576